| 腺苷对大鼠肺缺血-再灌注损伤的保护作用 |
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| 引用本文： | 李畅,马海涛,赵军,倪斌,郁珲. 腺苷对大鼠肺缺血-再灌注损伤的保护作用[J]. 江苏医药, 2011, 37(15) |
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| 作者姓名： | 李畅 马海涛 赵军 倪斌 郁珲 |
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| 作者单位： | 苏州大学附属第一医院心胸外科,215006 |
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| 摘 要： | 目的探讨腺苷对大鼠肺缺血-再灌注(I-R)损伤的保护作用。方法健康SD大鼠60只,随机均分为假手术(A)组、肺I-R(B)组、腺苷预处理(C)组。建立在体肺I-R模型,检测肺组织中髓过氧化物酶(MPO)活力、丙二醛(MDA)含量、超氧化物歧化酶(SOD)含量,并通过HE染色及透射电镜观察肺组织结构的变化。结果 C组MPO活力、MDA含量明显较B组低,而SOD含量明显高于B组(P<0.05)。HE染色可见B组明显毛细血管淤血、肺泡间质水肿、肺泡压缩;而C组仅见轻度肺泡间质水肿。透射电镜显示B组II型肺泡上皮细胞微绒毛数量减少,核固缩,板层体减少;而C组细胞器完整。结论腺苷对肺I-R损伤有保护作用,可能与抑制中性粒细胞聚集与激活,减轻肺组织水肿,减少氧自由基损害有关。
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| 关 键 词： | 腺苷 肺缺血-再灌注损伤 |
Protective effect of adenosine on lung ischemia-reperfusion injury |
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| LI Chang,MA Haitao,ZHAO Jun,et al.. Protective effect of adenosine on lung ischemia-reperfusion injury[J]. Jiangsu Medical Journal, 2011, 37(15) |
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| Authors: | LI Chang MA Haitao ZHAO Jun et al. |
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| Affiliation: | LI Chang,MA Haitao,ZHAO Jun,et al.Department of Thoracic and Cardiovascular Surgery,First Affiliated Hospital,Soochow University,Suzhou 215006,CHINA |
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| Abstract: | Objective To explore the protective effect of adenosine on lung ischemia-reperfusion(I-R) injury.Methods Sixty SD rats were randomly divided into 3 groups of A(sham operation),B(I-R) and C(adenosine preconditioning plus I-R) with 20 rats each.Myeloperoxidase(MPO),malondialdehyde(MDA) and superoxide dismutase(SOD) were measured and pulmonary structure was observed by HE staining and transmission electron microscope.Results MDA and MPO were lower,but SOD was higher,in group C than those in group B(P<0.05).Cap... |
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| Keywords: | Adenosine Lung ischemia-reperfusion injury |
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