Decreased galanin serum levels are associated with alcohol-craving during withdrawal |
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Authors: | Heberlein Annemarie Muschler Marc Frieling Helge Lenz Bernd Wilhelm Julia Gröschl Michael Kornhuber Johannes Bleich Stefan Hillemacher Thomas |
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Affiliation: | a Center for Addiction Research, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germanyb Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germanyc Department of Pediatrics, University Hospital Erlangen, Germany |
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Abstract: | BackgroundThe hypothalamic galanin expression has been associated with increased intake of carbohydrates and fats in preclinical studies. The appetite stimulating effect of galanin is thought to underlie the positive association between alcohol consumption and hypothalamic galanin expression observed in preclinical studies.MethodsIn this pilot study we investigated alterations in galanin serum levels (33 male patients) in alcohol-dependent patients during alcohol withdrawal (days 1, 7 and 14) in comparison to healthy controls (19 male controls). In order to assess the putative association between appetite regulation, galanin serum levels and alcohol consumption we additionally investigated the serum levels of insulin, glucose and triglycerides.ResultsThe galanin serum levels on day 1 of alcohol withdrawal were significantly reduced in the alcohol-dependent patients (T = − 3.302, p = 0.002) and increased significantly from day 1 to day 14 of alcohol withdrawal (F = 6.437, p = 0.002). We found a significant negative association between the galanin serum levels and alcohol craving measured by the Obsessive Compulsive Drinking Scale (OCDS) (r=−0.449, p=0.009) and the obsessive subscale of the OCDS (r = − 0.521, p = 0.002) on day 1 of alcohol withdrawal. There was no association between the galanin serum levels and the parameters of energy homeostasis (triglycerides, cholesterol, insulin, and glucose) investigated.ConclusionsAcute alcohol withdrawal was associated with decreased galanin serum levels in this pilot study. There was no association between the galanin serum levels and the parameters of energy homeostasis. Further research of galanin serum levels in active drinkers will be necessary to clarify the putative association between galanin serum levels, appetite regulation and alcohol consumption. |
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Keywords: | AAT, aspartate aminotransferase ALAT, alanine aminotransferase AUDIT-C, Alcohol Use Disorder Identification Test &mdash Alcohol Consumption Questions BAC, Breath Alcohol Concentration BDI, Beck's Depression Inventory BMI, body mass index CIWA-Ar, Clinical Institute Withdrawal Assessment for Alcohol DI, daily intake of alcohol in grams DSM-IV, Diagnostic and Statistical Manual of Mental Disorders GGT, gamma glutamyl transferase ICD-10, International Classification of Diseases LC, leukocyte count N.A., not available OCDS, Obsessive and Compulsive Drinking Scale SD, standard deviation SESA, Severity Scale of Alcohol Dependence STAI-I, State Anxiety, State and Trait Anxiety Inventory STAI-II, Trait Anxiety, State and Trait Anxiety Inventory TC, thrombocyte count YD, years of drinking |
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