Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis |
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| Authors: | Trzesniak Clarissa Kempton Matthew J Busatto Geraldo F de Oliveira Irismar Reis Galvão-de Almeida Amanda Kambeitz Joseph Ferrari Maria Cecília Freitas Filho Alaor Santos Chagas Marcos H N Zuardi Antonio W Hallak Jaime E C McGuire Phillip K Crippa José Alexandre S |
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| Affiliation: | a Department of Neuroscience and Behavioral Science, Medical School, University of São Paulo (USP), Ribeirão Preto (SP), Brazil and INCT Translational Medicine, Brazilb Department of Psychosis Studies, Institute of Psychiatry, King's College London, UKc Department of Psychiatry, Medical School, University of São Paulo (USP), São Paulo (SP), Brazild Affective Disorders Center, Universidade Federal da Bahia (UFBA), Salvador (BA), Brazile Post Graduation Program, Universidade Federal de São Paulo (UNIFESP), and Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), São Paulo (SP), Brazil |
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| Abstract: | Magnetic resonance imaging (MRI) studies have reported a variety of brain abnormalities in association with schizophrenia. These include a higher prevalence of an absent adhesio interthalamica (AI; also known massa intermedia), a gray matter junction that is present between the two thalami in approximately 80% of healthy subjects. In this meta-analytic review, we describe and discuss the main AI MRI findings in schizophrenia spectrum disorders (SSDs) to date. The MEDLINE and ISI Web of KnowledgeSM databases were searched up to December 2010, for studies that used MRI to assess AI in patients with SSD and controls. From fourteen potential reports, eleven were eligible to be part of the current review. These studies included 822 patients with SSD and 718 healthy volunteers. There was a large degree of variability in the MRI methods they employed. Patients with SSD had a higher prevalence of absent AI than healthy volunteers (odds ratio = 1.98; 95% confidence interval 1.33-2.94; p = 0.0008). This association was evident in both male and female SSD subjects, and there was no evidence that the prevalence was related to age or duration of illness. The significance of the absence of an AI for SSD may be clarified by studies in large, longitudinal community-based samples using standardized methods. |
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| Keywords: | AI, Adhesio interthalamica BDNF, Brain-derived neurotrophic factor MRI, Magnetic resonance imaging SANS, Scale for the Assessment of Negative Symptoms SSD, Schizophrenia spectrum disorder SPD, Schizotypal personality disorder |
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