Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder |
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Authors: | Bae Kyung-Yeol Kim Do-Won Im Chang-Hwan Lee Seung-Hwan |
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Affiliation: | a Department of Psychiatry, Chonnam National University Hospital, Gwangju, Republic of Koreab Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Koreac Clinical Emotion and Cognition Research Laboratory, Goyang-si, Republic of Koread Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Koreae Department of Psychiatry, Ilsan Paik Hospital, Inje University, Goyang-si, Republic of Korea |
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Abstract: | ObjectivePosttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relationship with symptom severity.MethodsERPs were recorded in 30 PTSD patients and 33 healthy controls while participants were performing the auditory oddball task. We compared P300 current source density data - obtained by standardized low-resolution brain electromagnetic tomography (sLORETA) - between the two groups. The correlation between P300 current source density and clinical symptoms (as evaluated using the Korean version of the Structured Interview for PTSD — K-SIPS and Davidson Trauma Scale — K-DTS) was conducted.ResultsIn PTSD patients, the current source density of P300 is significantly reduced in the inferior frontal gyrus, precentral gyrus, insula, and anterior cingulate compared to healthy controls. Total K-DTS scores were correlated with the P300 current source density in the posterior cingulate gyrus. The K-SIP B items (re-experiencing) and K-SIB D items (increased arousal) were positively correlated with P300 current source densities in several brain regions located in the frontal, parietal, and temporal lobe (p < 0.05). Conversely, the K-SIP C items (avoidance and numbing) were negatively correlated with P300 current source densities in the superior and middle frontal gyri in the frontal lobes (p < 0.05).ConclusionThe P300 current source densities reflected the pathophysiology of PTSD patients. PTSD symptoms were related to different neural activities, depending on their symptom characteristics. |
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Keywords: | PTSD, posttraumatic stress disorder ERP, event-related potential sLORETA, standardized low-resolution brain electromagnetic tomography K-SIPS, Korean version of the Structured Interview for PTSD K-DTS, Korean version of Davidson Trauma Scale SCID, Structured Clinical Interview for DSM MMPI, Minnesota Multiphasic Personality Inventory SSRIs, selective serotonin reuptake inhibitors BDI, Beck Depression Inventory HAMD-17, 17-item Hamilton Depression Scale HAMA, Hamilton Anxiety Scale |
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