Sunshine-exposure variation of human striatal dopamine D2/D3 receptor availability in healthy volunteers |
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Authors: | Hsiang-Yi Tsai Kao Chin Chen Yen Kuang Yang Po See Chen Tzung Lieh Yeh Nan Tsing ChiuI Hui Lee |
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Affiliation: | a Department of Psychiatry, St. Martin De Porres Hospital, Chiayi, Taiwanb National Cheng Kung University Hospital, Tainan, Taiwanc Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwand National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwane Department of Nuclear Medicine, National Cheng Kung University Hospital, Tainan, Taiwan |
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Abstract: | BackgroundIn addition to the serotonergic system, the central dopaminergic system has been reported to be correlated with seasonality. The aim of this study was to explore the difference in striatal dopamine D2/D3 receptor availability between healthy volunteers who had a high-sunshine exposure and those who had a low exposure.MethodsSixty-eight participants were enrolled, and those in the upper and lower quartiles in terms of sunshine exposure were categorized into high- (n = 17) and low-sunshine-exposure (n = 18) subgroups. Single photon emission computed tomography with [123I] iodo-benzamide was used to measure striatal dopamine D2/D3 receptor availability.ResultsStriatal dopamine D2/D3 receptor availability was significantly greater in the subjects with high-sunshine exposure than in those with low-sunshine exposure (F = 7.97, p = 0.01) after controlling for age, sex, and smoking status.LimitationsDifferent subjects were examined at different time points in our study. In addition, the sex and tobacco use distributions differed between groups.ConclusionThe central dopaminergic system may play a role in the neurobiological characteristics of sunshine-exposure variation. |
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Keywords: | ANCOVA, analysis of covariance BMI, body mass index CSF, cerebrospinal fluid IBZM, [123I] iodo-benzamide LH, luteinizing hormone MINI, Mini International Neuropsychiatric Interview ROI, regions of interest SAD, seasonal affective disorder SPECT, single photon emission computed tomography SD, standard deviations |
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