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Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes |
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| Authors: | Suk-Jae Park Ginnae Ahn Nam Ho LeeJae Woo Park You-Jin JeonYoungheun Jee |
| Affiliation: | a College of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University, Jeju 690-756, Republic of Korea b Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea c Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju 690-756, Republic of Korea d Department of Nuclear and Energy Engineering, Jeju National University, Jeju 690-756, Republic of Korea |
| Abstract: | Phloroglucinol (PG), a polyphenol compound of Eckloniacava known as brown algae abundant in Jeju island, has been proposed to exert the antioxidative and cytoprotective effects against oxidative stress. In this study, we confirmed that PG protected mice from damages caused by ionizing radiation and investigated its protection mechanism in detail. The result showed that PG increased the viability of splenocytes without cytotoxicity. Also, PG significantly enhanced the proliferation of splenocytes by limiting the increment of sub-G1 DNA contents via the inhibition of reactive oxygen species production in 2 Gy-irradiated splenocytes. In addition, PG significantly decreased DNA damage and the number of apoptotic fragments in lymphocytes against oxidative stress. Also, PG increased the counts of endogenous spleen CFUs, compared with only ionizing radiation-irradiated mice. These results demonstrate the multi-faceted protection mechanisms of PG in mice against oxidative stress caused by ionizing radiation, providing the benefit of inhibiting apoptosis and strengthening hematopoiesis. |
| Keywords: | Phloroglucinol Apoptosis Ionizing radiation |
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