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Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia |
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| Authors: | Niitsu Tomihisa Shirayama Yukihiko Matsuzawa Daisuke Hasegawa Tadashi Kanahara Nobuhisa Hashimoto Tasuku Shiraishi Tetsuya Shiina Akihiro Fukami Goro Fujisaki Mihisa Watanabe Hiroyuki Nakazato Michiko Asano Makoto Kimura Sho Hashimoto Kenji Iyo Masaomi |
| Institution: | |
| Abstract: | Brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations of serum BDNF levels with the cognition and clinical characteristics in patients with schizophrenia. Sixty-three patients with schizophrenia and 52 age- and sex-matched healthy controls were examined with neuropsychological tests. Serum BDNF levels were determined by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in serum BDNF levels between normal controls and patients with schizophrenia. Serum BDNF levels of normal controls showed negative correlations with verbal working memory, but this was not the case with schizophrenic patients. Meanwhile, serum BDNF levels of schizophrenic patients showed positive correlations with the scores of the Scale for the Assessment of Negative Symptoms (SANS) and the Information subtest scores of Wechsler Adult Intelligence Scale Revised (WAIS-R). Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia. |
| Keywords: | BDNF Brain-derived neurotrophic factor BMI Body-mass index BPRS Brief psychiatry rating scale DIEPSS Drug induced extrapyramidal symptoms scale DSDT Digit span distraction test ELISA Enzyme-linked immunosorbent assay IQ Intelligence quotient PANSS Positive and negative syndrome scale SANS Scale for the assessment of negative symptoms WAIS-R Wechsler adult intelligence scale revised WCST Wisconsin card sorting test |
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