The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study |
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Authors: | Tomson Katrin Merenäkk Liis Loit Helle-Mai Mäestu Jarek Harro Jaanus |
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Affiliation: | a Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Estoniab Department of Public Health, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Estoniac National Institute for Health Development, Estonian Centre of Behavioural and Health Sciences, Tallinn, Estoniad Institute of Sport Pedagogy and Coaching Science, University of Tartu, Estonia |
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Abstract: | The serotonin transporter gene promoter region polymorphism (5-HTTLPR) has been linked to psychiatric disorders, mostly anxiety and affective disorders. In elderly populations 5-HTTLPR polymorphism has also been reported to be associated with serum lipid levels. We have examined the interaction of the 5-HTTLPR polymorphism and the markers of lipid metabolism at young age in a longitudinal, population-representative cohort study. The sample of the Estonian Children Personality Behaviour and Health Study (initially cohorts of 9 and 15 year old children, complete lipid and genotype data for n = 1176) was examined throughout 10 years. Subjects were genotyped and the levels of low-density lipoproteins, high-density lipoproteins, triglycerides, and total cholesterol were measured. Children and adolescents carrying the s allele of the 5-HTTLPR polymorphism had lower levels of low-density lipoprotein and total cholesterol. At the age of 25, the s allele carriers had higher levels of high-density lipoproteins. These associations were independent of gender. Thus the 5-HTTLPR can be associated with the serum lipid levels and in particular low-density lipoproteins already in a young age. |
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Keywords: | HDL, high-density lipoproteins LDL, low-density lipoproteins SSRIs, selective serotonin re-uptake inhibitors 5-HTTLPR, serotonin transporter gene linked promoter region ECPBHS, Estonian Children Personality Behaviour and Health Study |
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