Institution: | a Department of Psychiatry, School of Medicine, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Julián Clavería 6-3°, 33006 Oviedo, Spainb Emergency Room, San Agustin Hospital, Camino de Heros 4, 33400 Avilés, Spainc National Suicide Research Foundation, 1 Perrott Avenue, College Road, Cork, Irelandd Unidad de Adolescentes, Department of Psychiatry, Hospital General Universitario Gregorio Marañon, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Ibiza 43, 28009 Madrid, Spaine Laboratory of Molecular Genetics, Central University Hospital of Asturias, Celestino Villamil sn, 33006 Oviedo, Spainf Mental Health Services of Asturias (SESPA), Maestros Martin Garlache sn, 33510 Pola de Siero, Spaing Unidad de Conductas Adictivas, Hospital Santa Maria Nai, CHOU, Ramón Puga 52-56, 32005 Ourense, Spain |
Abstract: | ObjectiveTo investigate whether functional polymorphisms directly (HTR2A and SLC6A4 genes) or indirectly (IL-1 gene complex, APOE and ACE genes) related with serotonergic neurotransmission were associated with suicidal behavior.Subjects and methods227 suicide attempters, 686 non-suicidal psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods.ResultsThere were no differences in genotype frequencies between the three groups. The −1438A/G χ2 (df) = 9.80 (2), uncorrected p = 0.007] and IL-1α −889C/T χ2 (df) = 8.76 (2), uncorrected p = 0.013] genotype frequencies between impulsive and planned suicide attempts trended toward being different (not significant after Bonferroni correction). Suicide attempts were more often impulsive in the presence of −1438G/G or IL-1α −889C/T or C/C genotypes. There was interaction between the polymorphism 5-HTTLPR and age LRT (df) = 6.84 (2), p = 0.033] and between the polymorphisms APOE and IL-1RA (86 bp)n LRT (df) = 12.21 (4), p = 0.016] in relation to suicide attempt lethality.ConclusionThese findings further evidence the complexity of the association between genetics and suicidal behavior, the need to study homogenous forms of the behavior and the relevance of impulsive and aggressive traits as endophenotypes for suicidal behavior. |