| 当归对CCl4致大鼠肝纤维化胶原蛋白含量的影响 |
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| 引用本文： | 王伟群,王柏欣,邵文武. 当归对CCl4致大鼠肝纤维化胶原蛋白含量的影响[J]. 黑龙江医药科学, 2003, 26(3): 25-25 |
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| 作者姓名： | 王伟群 王柏欣 邵文武 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的：本实验的目的是观察当归对四氯化碳(CCl4)致大鼠肝纤维化肝胜胶原蛋白含量的影响。方法：通过灌胃给当归于CCl4诱导的肝纤维化大鼠模型，相当于原生药的6g／kg、4g/kg和2g/kg,10周后，观察当归对肝脏胶原蛋白含量及肝胖组织病理学的影响。结果：当归组的胶原蛋白含量低于模型组，组织病理学也显示当归能减轻肝纤维化。结论：当归可抵抗肝纤维化，其机理可能与其抑制成纤维细胞的增殖和减少胶原纤维合成有关。
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| 关 键 词： | 当归 肝纤维化 |
| 文章编号： | 1008-0104(2003)03-0025-01 |
| 修稿时间： | 2003-03-21 |
The effect of Angelica on the content of liver collagen protein of hepatic fibrosis rats induced by CC14 |
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| WANG Wei-qun,WANG Bai-xin,SHAO Wen-wu. The effect of Angelica on the content of liver collagen protein of hepatic fibrosis rats induced by CC14[J]. Heilongjiang Medicine and Pharmacy, 2003, 26(3): 25-25 |
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| Authors: | WANG Wei-qun WANG Bai-xin SHAO Wen-wu |
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| Abstract: | Objectives: The purpose of the study was to observe the effect of Angelica on the content of liver collagen protein of hepatic fibrosis rats induced by CCl 4. Methods:The hepatic fibrosis rat model induced by CCl 4,was given by ig Angelica equal to crude drug 6g/kg, 4g/kg and 2g/kg.The effect of Angelica on the content of liver collagen protein and histopathology was observed.Results: The level of liver collagen protein in Angelica group was than that of the model group and histopathology also show that Angelica reduced hepatic fibrosis. Conclusion: Angelica may resist hepatic fibrosis.The mechanism is possibly that Angtlica may inhibit reproduction of fibroblast and reduce the synthesis of collagen fiber. |
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| Keywords: | Angelica hepatic fibrosis |
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