Hypoglycaemia in Type 2 diabetes |
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| Institution: | 1. Bariatric and Metabolic Institute, Department of General Surgery, Cleveland Clinic, Cleveland, Ohio;2. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio;3. Department of Surgery, University of Oklahoma, College of Medicine, Tulsa, Oklahoma |
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| Abstract: | Rates of hypoglycaemia in those with Type 2 diabetes newly started on insulin are less than in Type 1 diabetes but rise with time. As insulin secretion declines, the ability to release glucagon is diminished. Adrenaline release partially compensates for deficient glucagon secretion but is vulnerable to repeated hypoglycaemia leading to diminished sympathoadrenal activation. Thus the inevitable decline in endogenous insulin, eventually produces a similar failure of physiological protection to hypoglycaemia as in Type 1 diabetes. |
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