| 启东肝癌高发区饮用水对F—344大鼠肼—γ—GT酶影响的分析 |
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| 引用本文： | 周天伦 俞顺章. 启东肝癌高发区饮用水对F—344大鼠肼—γ—GT酶影响的分析[J]. 中华预防医学杂志, 1990, 24(4): 203-205 |
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| 作者姓名： | 周天伦 俞顺章 |
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| 摘 要： |
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| 关 键 词： | 肝癌 饮水 γ－GT 黄曲霉毒素 |
Laboratory study on the relationship between drinking water and hepatoma--quantitative evaluation using hepatic gamma-GT method |
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| T L Zhou,S Z Yu. Laboratory study on the relationship between drinking water and hepatoma--quantitative evaluation using hepatic gamma-GT method[J]. Chinese Journal of Preventive Medicine, 1990, 24(4): 203-205 |
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| Authors: | T L Zhou S Z Yu |
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| Affiliation: | School of Public Health, Shanghai Medical University. |
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| Abstract: | One to two-month-old male Fischer 344 (F-344) rats were used in this investigation. The experiment was devised simulating the Two-stage Hepatocarcinogenesis Model described by Pitot. Quantitative stereological method was applied to evaluate the gamma-GT enzyme altered foci (EAF) in examined liver slides. The results showed that pond-ditch water had an enhancement effect on the expression of gamma-GT in the livers of male F-344 rats, where as well water had no such effect. When AFB1 was given alone to the male F-344 rats after partial hepatectomy, there was no effect on gamma-GT, if it was followed by pond-ditch water the rats would express high frequency of EAF. In this experiment the effect of organochlorinated pesticide DDT on hepatic gamma-GT was also studied. It showed a strong influence on the quantity and size of EAF. |
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