Destructive arthritis in a patient with Haim-munk syndrome |
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Authors: | Lidar Merav Zlotogorski Abraham Langevitz Pnina Tweezer-Zaks Nurit Zandman-Goddard Gisele |
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Institution: | Department of Medicine B and Rheumatology Unit, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel. |
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Abstract: | Haim-Munk and Papillon-Lefèvre are 2 closely related syndromes, inherited in an autosomal recessive pattern, manifested by palmoplantar keratoderma and early, destructive periodontitis. Recently, mutations in the cathepsin C gene have been recognized in both syndromes. We describe a patient with Haim-Munk syndrome (palmar plantar keratosis and periodontitis) and destructive arthritis of the wrists and shoulder joints, an association that has not been previously described. |
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