| 均匀设计法优选大黄半仿生提取工艺 |
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| 引用本文： | 黄良永,孟斐,杨光义. 均匀设计法优选大黄半仿生提取工艺[J]. 中国药师, 2014, 0(9): 1499-1502 |
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| 作者姓名： | 黄良永 孟斐 杨光义 |
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| 作者单位： | 湖北医药学院附属太和医院 湖北十堰 442000；;湖北医药学院药学院;湖北医药学院附属太和医院 湖北十堰 442000 |
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| 摘 要： | 目的：优选大黄的半仿生提取工艺条件。方法：以芦荟大黄素、大黄酸、大黄素、大黄酚的总含量,总蒽醌含量和干浸膏得率为综合评价指标,采用均匀设计法优选大黄半仿生提取工艺。结果：通过优化并结合工业生产实际,确定三煎用水的pH依次为2.0、6.5、9.0;煎煮时间依次为：2,1,1 h。结论：本法为大黄的优化提取提供了理论依据。
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| 关 键 词： | 大黄 半仿生提取法 均匀设计 |
| 收稿时间： | 2014-03-10 |
| 修稿时间： | 2014-05-04 |
Optimization of Semi bionic Extraction Technology for Rhubard by Uniform Design |
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| Huang Liangyong,Meng Fei and Yang Guangyi. Optimization of Semi bionic Extraction Technology for Rhubard by Uniform Design[J]. China Pharmacist, 2014, 0(9): 1499-1502 |
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| Authors: | Huang Liangyong Meng Fei Yang Guangyi |
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| Affiliation: | Department of Pharmacy of Taihe Hospital, Hubei University of Medicine, Hubei Shiyan 442000, China;;Pharmacy College, Hubei University of Medioine,Hubei University of Medicine;Department of Pharmacy of Taihe Hospital, Hubei University of Medicine, Hubei Shiyan 442000, China; |
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| Abstract: | Objective： To optimize semi-bionic extraction （SBE） of rhubard. Methods： The best extraction conditions of semi- bionic extraction for rhubard were optimized by uniform design with the total content of loeemodin, rhein, emodin, chrysophanol, and anthraquinone and the dried extract weight as the indices. Results： According to the optimization and the industrial production condition, the pH values of water in three times of extraction were 2.0,6.5 and 9. 0, and the extraction time was 2, 1, 1 h, respectively. Conclusion： This method provides a theoretical basis for the optimization of rhubard extraction. |
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| Keywords: | Rhubard Semi-bionic extraction Uniform design Extraction process |
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