| 盐酸吡格列酮缓释微丸胶囊制备及体外释放特性 |
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| 引用本文： | 王颖莹,崔新刚,陈洪轩.盐酸吡格列酮缓释微丸胶囊制备及体外释放特性[J].中国药师,2014(9):1503-1505. |
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| 作者姓名： | 王颖莹 崔新刚 陈洪轩 |
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| 作者单位： | 解放军第150中心医院 河南洛阳471031；;解放军第150中心医院;解放军第150中心医院 河南洛阳471031； 2.黄河科技大学医学院 |
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| 摘 要： | 目的：制备盐酸吡格列酮缓释微丸胶囊并考察其体外释放特性。方法：底喷式流化床包衣制备盐酸吡格列酮缓释微丸,通过正交设计优化处方。结果：该方法简单易操作,所选处方工艺重复性良好,所制备微丸具有明显缓释作用。结论：该包衣处方及制备工艺简便可控,缓释微丸稳定性良好。
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| 关 键 词： | 盐酸吡格列酮 流化床 微丸 缓释 包衣 |
| 收稿时间： | 3/3/2014 12:00:00 AM |
| 修稿时间： | 2014/5/20 0:00:00 |
Preparation and in vitro Dissolution of Pioglitazone Hydrochloride Sustained-release Pellet Capsules |
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| Wang Yingying,Cui Xingang and Chen Hongxuan.Preparation and in vitro Dissolution of Pioglitazone Hydrochloride Sustained-release Pellet Capsules[J].China Pharmacist,2014(9):1503-1505. |
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| Authors: | Wang Yingying Cui Xingang and Chen Hongxuan |
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| Institution: | Wang Yingying , Cui Xingang ,Chen Hongxuan (1. The 150th Central Hospital, PLA, Henan Luoyang 471031, China ;2. Huanghe Sci- ence and Technology College) |
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| Abstract: | Objective： To prepare pioglitazone hydrochloride （PGH） sustained-release pellet capsules and study the in vitro disso- lution. Methods： The preparation was prepared with a bottom spray fluidized bed, and the formula and technology were optimized by orthogonal test. Results： The method was simple and easy to operate, the reproducibility of the formula and technology was good, and the pellets had obvious sustained-release property. Conclusion： The formula and technology are easy and controllable, and the stability of sustained release pellets is good. |
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| Keywords: | Pioglitazone hydrochloride Fluidized bed Pellets Sustained release Coating |
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