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The in vivo distribution of indium-111 labeled in vitro alloactivated syngeneic lymphocytes in a patient with relapsed acute myelomonocytic leukemia: implications for adoptive chemoimmunotherapy |
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| Authors: | P M Sondel P C Kohler J A Hank M J Bozdech L M Lieberman R Hong R Albertini R E Exten |
| Affiliation: | 1. Department of Pediatrics, of the University of Wisconsin, Madison, Wisconsin, U.S.A.;2. Department of Human Oncology, of the University of Wisconsin, Madison, Wisconsin, U.S.A.;3. Department of Genetics of the University of Wisconsin, Madison, Wisconsin, U.S.A.;4. Department of Medicine, of the University of Wisconsin, Madison, Wisconsin, U.S.A.;5. Department of Medicine at the University of Vermont, Burlington, Vermont, U.S.A. |
| Abstract: | A single patient who had a leukemic relapse six months after receiving a syngeneic bone marrow transplant was given "adoptive chemoimmunotherapy." Lymphocytes from the patients identical twin were alloactivated and grown in T cell growth factor in vitro. After receiving chemotherapy to reduce the number of relapsed leukemia cells, he received 1.1 X 10(10) in vitro alloactivated twin lymphocytes via intravenous and intraperitoneal injections. Although progressive Candidal pneumonia was fatal and prevented analysis of either efficacy or delayed toxicity of this potential form of therapy for this patient, radioactive 111In labelling and scanning showed dissemination of these lymphocytes following either injection route, with no clinical evidence of immediate toxicity. |
| Keywords: | Adoptive immunotherapy acute myelomonocytic leukemia cell mediated lysis assay peripheral blood lymphocytes T cell growth factor intravenously intraperitoneally |
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