Antiepileptogenic and anticonvulsant activity of interleukin-1 beta in amygdala-kindled rats |
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Authors: | Sayyah M Beheshti S Shokrgozar M A Eslami-far A Deljoo Z Khabiri A R Haeri Rohani A |
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Affiliation: | Department of Physiology and Pharmacology, Institute Pasteur of Iran, Tehran, Iran. sayyah@pasteur.ac.ir |
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Abstract: | Ischaemic, excitotoxic and traumatic brain injuries have been associated with the occurrence of epileptic seizures. Microglia, the principal immune cells in the brain, produce a variety of proinflammatory and cytotoxic factors especially interleukin-1 (IL-1) early after an acute insult. We studied the effect of intracerebroventricularly administered IL-1beta on seizure acquisition and on fully kindled seizures in amygdala kindling model of epilepsy. IL-1beta (0.01 ng/rat) retarded acquisition of kindled behavioral seizures and growth of afterdischarges (AD). IL-1beta (0.01-10 ng/rat) also exhibited significant anticonvulsant effect on established kindled seizures and AD duration. This effect began 0.5 h after administration and was continued up to 72 h. Pretreatment of the kindled animals with nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, or cyclooxygenase inhibitor, piroxicam, reversed the anticonvulsant effect of IL-1beta at early time points. Although most of the previous studies indicate a proconvulsant or convulsant property of IL-1, our results support a protective and antiepileptogenic role of IL-1beta. |
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Keywords: | Amygdala kindling Interleukin-1β Seizure Nitric oxide Prostaglandins |
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