胃肠道间质瘤32例临床病理分析

目的:探讨胃肠道间质瘤(GIST)的组织病理形态学和免疫组织化学特点。方法:用CD117、CD34、SMA、Desmin、S-100蛋白质抗体通过免疫组织化学SP法对原发性GIST进行研究。结果:本组GIST主要发生在胃(65.6%),常以上消化道出血为首发症状。肿瘤基本组织形态为梭形细胞和上皮样细胞。免疫组化染色CD117和CD34阳性率分别为90.6%和81.3%。结论:GIST好发生在中老年,肿瘤细胞形态多变和排列方式多样,免疫组织化学染色为CD117、CD34阳性、Desmin阴性,S- 100蛋白和SMA不表达或者呈灶状阳性,肿瘤细胞直径≥5 cm,核分裂像大于5个/50 HP可作为恶性参考指标。

Analysis of the Cljnicopathology on 32 Gastrointestinal Stromal Tumors

Objective:To explore the histopathological and immunohistochemical feature of astrointestinal tumors.Methods: Immunohistoehemical staining were performed in the primary gastrointestinal tumors for a panel of antibodies such as CD117, CD34,SMA,Desmin,S-100 by SP methods.Results:The tumors mainly were located in the stomach(65.6%).The primary cell morphology consisted of spindle shaped cells and epithelioid cells.Immunohistoehemically,the positive rates of CD117 and CD34 were 90.6% and 81.3% respectively.Conclusion:GISTs predominantly occurred in middle aged or older patients,with various kinds of cell types and different arrangements.Immunohistochemical staining was positive for CD117 and CD34,nega- tive for desmin,focal positive or absent for S-100 protein and SMA.The tumors are over or equal 5 cm in diameter,mitotic count is over 5/50 HP might help to identify tumors with malignant potential.