脂联素及氧化修饰低密度脂蛋白在子痫前期中的测定及意义

目的测定脂联素和氧化修饰低密度脂蛋白(oxLDL)在子痫前期中的变化,探讨其意义。方法采用酶联免疫吸附法测定子痫前期组及对照组血清脂联素及oxLDL水平。结果(1)子痫前期组与对照组孕妇血清脂联素比较虽未见显著差异,但子痫前期重度组、子痫前期轻度组、对照细依次呈下降趋势。(2)子痫前期组与对照组血清oxLDL比较,见子痫前期重度组升高,与对照组比较有显著差异(P<0.01);子痫前期重度组较子痫前期轻度组升高,两组比较有显著差异(P<0.05);子痫前期轻度组虽较对照组升高,但两组比较无显著差异。(3)将血清脂联素与oxLDL水平进行相关性检验,在子痫前期组两者呈负相关(r=-0.64,P<0.05)。(4)子痫前期重度组血清脂联素与收缩压、舒张压呈负相关(r=-0.49,P<0.05;r=-0.42,P<0.05)。结论脂联素和oxLDL可能是子痫前期发病的重要因素。

Level and significance of adiponection and oxidant low-density lipoproteins in serum of preeclampsia

Objective:To study the change and clinical significance of adiponection and oxidant low-density lipoproteins(oxLDL)level in serum of preeclampsia.Methods:The level of adiponection and oxLDL in serum were measured with ELISA.Results:1.There was no difference in serum adiponection among three groups.However,there was a decreasing trend for severe preeclampsia,light preeclampsia and control group.2.The oxLDL level was significantly higher in severe preeclampsia compared with control group(P<0.01);the oxLDL level was higher in severe preeclampsia compared with light preeclampsia,but had no difference between two groups(P>0.05).It was in the same situation between slight preeclampsia and control group.3.There was a negative correlation between adiponection and oxLDL level among three groups(r=-0.64,P<0.05).4.There was a negative correlation between adiponection and systolic and diatolic blood pressure(r=-0.49,P<0.01;r=-0.42,R<0.05).Conclusion: Adiponection and oxLDL might be important factors for occurrence of preeclampsia.