Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense |
| |
Authors: | Wang Wei Zeng Yi Han Osman Khadijo Shinde Kamlesh Rahman Mukhlesur Gibbons Simon Mu Qing |
| |
Affiliation: | School of Pharmacy, Fudan University, Shanghai, People's Republic of China. |
| |
Abstract: | Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 μg/mL (8.4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|