| 细胞内信号转导分子——Smad7在人牙胚发育中的表达和意义 |
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| 引用本文： | 包柳郁,牛忠英,史俊南,汪平.细胞内信号转导分子——Smad7在人牙胚发育中的表达和意义[J].华西口腔医学杂志,2003,21(6):438-440. |
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| 作者姓名： | 包柳郁 牛忠英 史俊南 汪平 |
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| 作者单位： | 710032 第四军医大学口腔医院牙体病科(包柳郁,史俊南,汪 平),解放军306医院口腔科(牛忠英) |
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| 基金项目： | 国家自然科学基金资助项目 (编号 39870 789) |
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| 摘 要： | 目的 探讨Smad7在TGF-β调节牙胚发育过程中的作用。方法 采用免疫组化ABC法观察Smad7在人牙胚发育各个时期的表达分布及其变化情况。结果 人牙胚发育各个时期均表达Smad7,但各期分布模式有所不同。Smad7在不同发育时期牙胚中的分布与TGF-β及其特异的信号转导分子Smad2、3有相似之处。结论 Smad7 可能在TGF-β调节成釉细胞和成牙本质细胞分化的信号转导通路中起一定的作用。
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| 关 键 词： | Smad7 牙胚发育 免疫组织化学 |
| 收稿时间： | 2003-12-25 |
| 修稿时间： | 2002年9月4日 |
The Expression and Function of Smad7 During Human Tooth Germ Development |
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| BAO Liuyu ,NIU Zhongying,SHI Junnan,et al..The Expression and Function of Smad7 During Human Tooth Germ Development[J].West China Journal of Stomatology,2003,21(6):438-440. |
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| Authors: | BAO Liuyu NIU Zhongying SHI Junnan |
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| Institution: | *Department ofOperative Dentistry and Endodontics,Stomatological Col- lege,the Fourth MilitaryMedical University,Xi’an710032,China |
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| Abstract: | OBJECTIVE: To observe the temporal and spatial expression of Smad7 during human tooth germ development and evaluate the effect of Smad7 on tooth germ development. METHODS: The expression of Smad7 and its changes at different stages of human tooth germ were detected by using immunohistochemical staining. RESULTS: Smad7 was expressed at all stages of tooth germ, but the distribution patterns at various stages were different. It indicated that temporal and spatial expressing mode of Smad7 during human tooth germ development was specific, which was similar to that of TGF-beta its signal transducer Smad2/3. CONCLUSION: Smad7 might play an important role in TGF-beta intracellular signaling for modulating the differentiation of ameloblasts and odontoblasts. |
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| Keywords: | Smad7 tooth germ development immunohistochemistry |
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