| STAT3、CA125在人肺腺癌细胞A549中的表达及意义 |
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| 引用本文： | 蓝秀,王超,辛彩霞,宋本艳,王鸿程.STAT3、CA125在人肺腺癌细胞A549中的表达及意义[J].泸州医学院学报,2011,34(6):650-652. |
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| 作者姓名： | 蓝秀 王超 辛彩霞 宋本艳 王鸿程 |
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| 作者单位： | 泸州医学院附属医院呼吸内科,四川泸州,646000 |
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| 基金项目： | 四川省科技厅重点资助基金项目(2006J13-92) |
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| 摘 要： | 目的：探讨信号转导和转录激活因子3（STAT3）对肺腺癌的诊断价值。方法：采用免疫组织化学PV二步法检测人肺腺癌细胞A549和正常人胚肺细胞MRC－5中STAT3、CA125蛋白表达，分析在人肺腺癌细胞A549中STAT3与CA125表达的相关性。结果：STAT3、CA125在人肺腺癌细胞A549中的阳性表达水平均明显高于正常人胚肺细胞MRC-5（P〈0．01），且在人肺腺癌细胞．8549中STAT3与临床上常用的肺肿瘤标志物CA125的表达均呈正相关。结论：STAT3有望成为一种新的肺肿瘤标志物推荐临床使用。
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| 关 键 词： | 肺腺癌 STAT3 CA125 肺肿瘤标志物 |
EXPRESSION AND SIGNIFICANCE OF STAT3 AND CA125 IN LUNG ADENOCARCINOMA CELL A549 |
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| Lan Xiu,et al.EXPRESSION AND SIGNIFICANCE OF STAT3 AND CA125 IN LUNG ADENOCARCINOMA CELL A549[J].Journal of Luzhou Medical College,2011,34(6):650-652. |
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| Authors: | Lan Xiu |
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| Institution: | Lan Xiu,et al Department of Respiratory,the Central Hospital of Lishui |
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| Abstract: | Objective:To investigate the diagnostic value of STAT3 in lung adenocarcinoma.Methods:Expression of protein of STAT3 and CA125 in lung adenoc arcinoma cell A549 and human normal lung cell MRC-5 were tested by immunohistochemical staining(PV).The correlation between STAT3 and CA125 in lung adenocarcinoma cell A549 was analyzed.Results:(1)The protein levels of STAT3 and CA125 in lung adenocarcinoma cell A549 were apparently higher than that in human normal lung cell MRC-5(P<0.01).The expression level of STAT3... |
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| Keywords: | Lung adenocarcinoma STAT3 CA125 Lung tumor marker |
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