肝癌肝动脉、门静脉双途径栓塞化疗的临床观察

目的观察中晚期肝癌肝动脉、门静脉双途径栓塞性化疗及在此基础上综合治疗的疗效。方法40例肝癌患者随机分为A、B两组。A组20例行肝动脉碘油栓塞化疗(TAE)及无水酒精注射(PEI)治疗;B组20例在肝动脉碘油栓塞化疗1~3次后予门静脉碘油栓塞化疗(PVE)及无水酒精注射治疗。结果近期疗效,A、B两组接受治疗后肿块均有不同程度缩小,且B组优于A组,远期疗效,A组接受治疗后1、2、3年的生存期分别是55%、25%、5%;B组为75%、35%、10%,统计学上具有显著性意义,P<0.05。在治疗期间没有出现严重并发症。结论肝动脉、门静脉双途径碘油栓塞化疗联合无水酒精注射治疗,取得较好治疗效果,能有效延长肝癌患者的生存期,是目前中晚期肝癌综合治疗中比较满意的治疗方法。

The clinical observation of hepatic artery and portal vein e mbolic chemotherapy in the treatment of Intermediate and advanced hepatocelluar carcinoma

Objective To observe the effect of hepatic artery and portal vein embolic chemotherapy in combination with alcohol injection in the treatment of intermediate and advanced hepatocelluar carcinoma. Methods Among 40 cases of advanced hepatocelluar carcinoma, the 20 cases of group A were treated with hepatic artery perfusion iodide chemotherapy and alcohol injection; the 20 cases of Group B were treated with hepatic artery and alcohol injection together with portal vein perfusion iodide chemotherapy. Results Curative effect in near future: After the treatment, all tumors both group A and B decreased in size in different level, group A was better than B, Curative effect in long term:the survival rates of group A in the 1st,2nd and 3rd year were 55%,25%,and 5%; the survival rates of group B were 75%,35%,and 10%.The difference was statistically significant (P<0.05). No serious complication were encountered during or after treatment. Conclusion The treatment with hepatic artery and portal vein embolic chemotherapy in combination with alcohol injection obtains a better result and it helps to prolong the patient's survivl time, so it is one of the best satisfied treatments for advanced hepatocelluar carcinoma.