Isolated central nervous system relapse of testicular cancer. |
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Authors: | J J Perry J S Jelinek |
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Institution: | Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20307-5001. |
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Abstract: | Central nervous system involvement with testicular cancer usually occurs with advanced systemic disease. Isolated CNS disease at relapse is rare. We report a patient who developed a solitary brain metastasis with no other systemic disease after having achieved a complete response to frontline therapy. After combined modality therapy for the CNS disease, the patient has remained disease-free for more than 3 years. The literature regarding brain metastases in relapsed testicular cancer is reviewed, including nine cases of isolated brain metastases. The CNS can be a "sanctuary" site for testicular cancer, and in the unusual subset of patients with isolated brain relapse, long-term remission is possible with aggressive therapy. |
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