脑动脉粥样硬化斑块的分布及其临床意义

目的：为我国研究脑血管疾病提供脑动脉粥样硬化形态学基础。方法：全脑血管造影检查结果阳性患者259例，对其斑块的发生部位以及与高血压、糖尿病及高血脂状态等合并症的关系进行分析。结果：脑动脉粥样硬化的好发部位主要为颈内动脉起始部和椎动脉起始部，其次为大脑前动脉、大脑中动脉和锁骨下动脉。27．6％合并糖尿病，24．1％合并高脂血症，58．7％合并高血压。结论：脑动脉粥样硬化是多因素疾病，脑动脉粥样硬化斑块以多病变、双侧共同病变及复杂病变为主。

Clinical Significance for the Distribution of Cerebral Atherosclerosis

Objective:To provide the morphological evidence of cerebral atherosclerosis (CAS) for investigating cerebrovascular disease (CVD).Methods:259 cases with CAS were confirmed by aortocranial angiography. The relationship between the locations of CAS and complications such as hypertension, diabetes, hyperlipemia and et al, was analyzed retrospectively.Results:The predilection sites of CAS are the originated regions of internal carotid artery and vertebral artery; next are anterior cerebral artery, middle cerebral artery and subclavian artery. 27.6% of the patients with CAS were complicated by diabetes, 24.1% by hyperlipemia, and 58.7% by hypertension.Conclusion:The CAS is a disease affected by multiple factors, its plaques predominantly present as two or more lesions, hibateral lesions and complicated pathological changes.