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Relationship between leukocytic infiltration and endothelial specialization in murine cardiac allografts |
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| Authors: | Douglas M. Leppink D.Keith Bishop Daniel D. Sedmak Charles G. Orosz |
| Affiliation: | a From the Department of Surgery, The University of Utah School of Medicine, Salt Lake City, Utah, USA b Department of Pathology, The Ohio State University College of Medicine, USA c The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA d Division of Hematology/Oncology, The University of Utah School of Medicine, Salt Lake City, Utah, USA |
| Abstract: | We have used immunologic and histologic techniques to analyze the rejection of heterotopic murine cardiac allografts. These studies were designed to test the hypothesis that lymph-node-like mechanisms of lymphocyte extravasation develop in immediately vascularized organ allografts during the process of rejection. The experimental results suggest that lymph-node-like mechanisms are not involved, and that an unexpected pattern of lymphocyte infiltration develops in these allografts. |
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