The Effect of Cranial Irradiation on Blood-Brain Barrier Permeability to Methotrexate |
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| Authors: | R S SESHADRI R G RYALL M S RICE MARGARET LEAHY R ELLIS |
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| Institution: | Departments of Haematology, Flinders Medical Centre, and The Adelaide Children's Hospital, Adelaide, S.A. |
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| Abstract: | Seshadri, R. S., Ryall, R. G., Rice, M. S., Leahy, Margaret, and Ellis, R. (1979). Aust. Paediatr. J. , 15, 184–186. The Effect of cranial irradiation on blood-brain barrier permeability to methotrexate. Methotrexate (MTX) was given orally (30 mg/m2) to 14 patients with leukaemia/lymphoma before and soon after cranial irradiation (Cl). The MTX levels in plasma and cerebrospinal fluid were measured three hours after the administration of MTX. Markedly increased blood-brain barrier (BBB) permeability of MTX was found in both asymptomatic and symptomatic patients with central nervous system (CNS) disease even before Cl. Successful treatment of the CNS disease decreased the BBB permeability to MTX. Cl per se did not increase the BBB permeability. |
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