A群流脑多糖菌苗应急接种及持续四年免疫效果观察

本文使用流脑A群多糖菌苗对10万名6个月~15岁儿童进行了应急接种及持续4年的免疫效果观察。接种后人体反应较轻,未见异常反应。应急接种后发病率迅速明显下降,免后一周保护率为81.23%、二周后87.17%,免后1~3年每年保护率80%以上。103名儿童的血清抗体免后一周上升4.77倍,二周后上升6.23倍,抗体4倍增长率为57.28%,连续三年两组儿童血清抗体GMT具有显著性差异与流行病学结果一致。因而本菌苗应急接种是成功的。接种后抗体上升快,可于1~2周内减少发病控制流行,人群免疫力可持续三年。

The Preventive Effectiveness of an Urgent Mass Vaccination with Purified Meningococcal Polysaccharide Vaccine Observed in a Meningitis Epidemic

The authors have observed the effectiveness of an urgent mass vaccination with purified meningocaccal polysaccharide vaccine among 108,402 infants and children aged between 6 months and 15 year-old in Yunyang county,Sichuan,during 1981 to 1984. Slight and middle grade reaction after 24 hours of the vaccination were found among 98% of the recipients; and serious reaction was only 1%. None of them had abnormal reaction.
Among 108,402 infants and children, 57, 808 were in the vaccination group and 46,994 in the control group.The prevalence in the urgent vaccination group was decreased rapidly and markedly. The protection rate after one-week of the vaccination was 81.23%; 87.17% after two-week; and 80% after vaccination during the subsequent three years. Among the 103 serological tested children, the geometric mean titer (GMT) after one-week of the vaccination was increased to 4,77-fold; 6.23-fold after two-week of the vaccination as compared with the GMT before vaccination. The children with 4-fold antibody titer increase was calculated as 57.28% of the vaccinated children.The GMTs both in the vaccinated and control groups showed statistical significance,corresponding with the epidemiological results.
we conclude that the urgent mass vaccination with this vaccine was successful with safety,gave rise to increase of antibody titers and created preventive effects.The prevalence of the disease was controlled within two weeks.The immune protective effect among vaccinated population may persist for three years.