| 紫外分光光度法测定脂质体中阿米卡星的含量 |
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| 引用本文： | 张伟,邓英杰.紫外分光光度法测定脂质体中阿米卡星的含量[J].沈阳药科大学学报,2000,17(6):422-423,426. |
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| 作者姓名： | 张伟 邓英杰 |
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| 作者单位： | 沈阳药科大学药学系沈阳 110015 |
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| 摘 要： | 应用紫外分光光度法 (经Hantzsch衍生化 )测定脂质体中阿米卡星的含量 .平均回收率为(10 0 5± 1 7) % (n =5 ) ,线性范围为 10～ 6 0 μg/mL .方法准确度高、重现性好 .
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| 关 键 词： | 脂质体 阿米卡星 Hantzsch反应 紫外分光光度法 |
Ultraviolet Spectrophotometric Determination of the Content of Amikacin in Liposomes |
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| Zhang Wei,Deng Yingjie.Ultraviolet Spectrophotometric Determination of the Content of Amikacin in Liposomes[J].Journal of Shenyang Pharmaceutical University,2000,17(6):422-423,426. |
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| Authors: | Zhang Wei Deng Yingjie |
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| Institution: | Zhang Wei,Deng Yingjie Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015 |
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| Abstract: | A chemical method was developed for the quantitive determination of amikacin in liposomes.By adapting the Hantzsch reaction,amikacin could be determined via the dihydrolutidine derivative using UV spectrophotometry.The standard curve for amikacin was linear in the range of 10～ 60 μg/mL ( r = 0 999 1 , n =3).The average recovery was (100 5±1 7)%( n =5).The procedure is simple,rapid and reliable. |
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| Keywords: | liposomes amikacin Hantzsch reaction UV spectrophotometry |
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