精神分裂症患者事件相关电位MMN对照研究

目的探讨精神分裂症患者事件相关电位失匹配负波(mismatch negativity,MMN)的特征及发病次数对MMN的影响。方法对35例精神分裂症患者(病例组)和30名志愿者(对照组)行事件相关电位MMN的检测,并比较首发病患与复发病患MMN潜伏期、波幅的差异。结果①病例组和对照组Fz,Cz点均可见较明显MMN波形,精神分裂症组波形欠规则。②相对于对照组而言,病例组在Fz,Cz点潜伏期没有显著性变化,而波幅降低,差异具有统计学意义(P<0.05)。③首发病患和复发病患MMN的潜伏期和波幅差异均没有统计学意义。结论精神分裂症患者存在认知功能缺陷,MMN可以为其提供临床参考,且MMN是一个素质性指标,与发病次数没有显著性相关。

Event-related potential mismatch negativity study in patients with schizophrenia

Objective To explore the characteristics of mismatch negativity(MMN)in schizophrenia and the effect of morbidity frequency on MMN.Methods A total of 35 cases of schizophrenia and 30 cases of normal controls were enrolled.The event-related potential MMN was measured,and the difference of MMN between patients with the first episode and the relapse of schizophrenia was compared.Results①All subjects had obvious MMN in Fz and Cz.The wave shape of schizophrenia patients was irregular.②Compared with normal controls,the latency had no obvious change at Fz,Cz in patients,but the aptitude significantly decreased at Fz,Cz(P <0.05).③The latency and the aptitude showed no significant difference between patients with the first episode and the relapse of schizophrenia.Conclusion Patients with schizophrenia have cognitive function impairment.MMN is a trait index and is not significantly related with the morbidity frequency.