家族性与散发性特发性震颤患者临床特征比较

目的比较家族性与散发性特发性震颤患者临床特征是否存在差异。方法临床确诊的ET患者88例,根据有无家族史,分为家族性ET和散发性ET。比较两组在性别、起病年龄、起病部位、震颤类型、震颤演变过程、最严重部位、是否对称、加重或减缓因素等方面的异同。结果家族性ET 45例和散发性ET 43例。家族性ET患者平均起病年龄早于散发性ET患者平均起病年龄[(33.48±18.87)岁vs(42.19±18.80)岁,P<0.05];两组间震颤类型及起病部位无明显差异;家族性ET患者震颤评分高于散发性者(4.34±2.22 vs 3.37±2.00,P<0.05)。家族性ET患者饮酒后震颤减轻或缓解明显高于散发性者(11/13 vs 4/10,P<0.05)。结论与散发性ET患者比较,家族性ET发病较早,进展较快,震颤较重,饮酒后震颤减轻更多。

Comparative study on clinical features of familial and sporadic essential tremor

Objective To compare the difference of clinical features between familial and sporadic essential tremor(ET)patients. Methods A total of 88 ET patients clinically diagnosed were collected and divided into familial and sporadic ET groups.The age,gender, type and position of tremor and other information were recorded and analyzed.Results Compared with sporadic ET patients,the average onset age of familial ET patients was younger,and there was statistical difference(P<0.05).The tremor scale of familial ET patients was significantly higher than that of sporadic ET patients(P<0.05).There was no statistical difference in type and position of tremor between two groups.The tremor was more likely to be relieved by alcohol in familial ET patients than in sporadic ET patients. Conclusion Familial ET patients and sporadic ET patients have different clinical features.Familial ET patients is much more severe and progress faster than sporadic ET patients.