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对rt-PA治疗脑梗塞中颈动脉粥样硬化影响的再讨论
引用本文:李威,Paul TROUILLAS.对rt-PA治疗脑梗塞中颈动脉粥样硬化影响的再讨论[J].中国临床神经科学,2000,8(2):92-95.
作者姓名:李威  Paul TROUILLAS
作者单位:1. 上海第二医科大学附属第九人民医院神经内科,200011
2. 法国里昂第一大学医学院Pete-Wethemen神经病学医院神经内科
摘    要:目的人体组织纤维蛋白溶解酶原酶(t-PA)治疗不同病因脑梗塞的疗效的再探讨。方法以颈动脉和心脏Doppler超声和数字式血管造影(DSA)的检查结果为依据作分组对比分析rt-PA的治疗效果。结果rT-PA治疗后24h症状改善与预后有关。颈动脉粥样硬化性完全梗塞和严重狭窄组病例溶栓起效时间明显推迟(P<0.05)。3个月后颈动脉完全梗塞组68.75%有严重神经系统后遗症。结论颈动脉粥样硬化性梗塞和严重狭窄是影响溶栓治疗预后的一个重要因素。

关 键 词:动脉粥样硬化  脑梗塞  溶栓治疗  rt-PA
修稿时间:1999-07-25

Discussing Again the Effect of Carotid Athroma on the Cerebral Infarction Treated by rt-PA
LI Wei,Paul TROUILLAS.Discussing Again the Effect of Carotid Athroma on the Cerebral Infarction Treated by rt-PA[J].Chinese Journal of Clinical Neurosciences,2000,8(2):92-95.
Authors:LI Wei  Paul TROUILLAS
Institution:LI Wei (Department of Neurology, Shanghai Ninth Hospital, Shanghai Second Medical University.Shanghai,200011)pAUL TROUILLAS (Service du Neurologie B, Hopital Heurologique de Pere-Wethemen,69003 LYON,La France)
Abstract:Aim: To discuss the result of therapy with rt-PA in cerebral infarction with different etiology. Methods: The grouping in etiology was constituted with the results of carotid and cardiac echo-Doppler and digital subtract angiography (DSA) to compare and analyse the effect of rt-PA. Results: It is correlated between the prognosis and the recuperation in 24h after rt-PA. The duration from therapy of thrombolysis to clinical syndrome ameliorated was more prolonged in groups of atheroma thrombosis and severe stenosis (P<0.05). 68.75% of cases with a severe handicap in the group of atheroma thrombosis after 3 months. Conclusion:Carotid atheroma thrombosis and severe stenosis are an important factor to interrupt the result of thrombolyse.
Keywords:atheroma  cerebral infarction  thrombolyse  rt-PA
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