Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats |
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| Authors: | Kim Mi-Ja Lee Hee Jae Wiryowidagdo Sumali Kim Hye Kyung |
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| Affiliation: | Department of Obesity Management, Graduated School of Obesity Science, Dongduk Women's University, Seoul, Republic of Korea. |
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| Abstract: | Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not given GPE (P < .05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphate kinase, and increased nitric oxide (NO), a known vasodilator, compared with the non-GPE-administered SHR group (P < .05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hypertension through increasing NO production in blood vessels. |
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