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| CYP2C10基因多态性对奥美拉唑治疗十二指肠溃疡的影响 | |
| 引用本文： | 李浩,吴金术,张伟,龚连生,刘刚,刘勤,谭亮,王荣兵. CYP2C10基因多态性对奥美拉唑治疗十二指肠溃疡的影响[J]. 中国内镜杂志, 2011, 17(8) |
| 作者姓名： | 李浩 吴金术 张伟 龚连生 刘刚 刘勤 谭亮 王荣兵 |
| 作者单位： | 1. 湖南省人民医院肝胆外科,湖南长沙,410002 2. 中南大学临床药理研究所,湖南长沙,410078 3. 中南大学湘雅医院卫生部肝胆肠外科中心,湖南长沙,410008 |
| 摘 要： | 目的 探讨奥美拉唑治疗十二指肠溃疡合并幽门螺旋菌感染的疗效及其与CYP2C19基因多态性的关系.方法 应用奥美拉唑+阿莫西林+克拉霉素三联用药1周后单用奥美拉唑抑酸3周的方案治疗65例经胃镜证实的十二指肠溃疡合并幽门螺旋菌( Hpylori)感染患者.记录治疗前和用药后症状的变化,并于治疗结束时复查胃镜.患者CYP2C19的基因型检测采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析方法.结果 65例十二指肠溃疡患者中,24例为纯合子强代谢者,31例为杂合子强代谢者,10例为弱代谢者.纯合子强代谢组、杂合子强代谢组和弱代谢组有效率分别为75.0％、90.3％和100％,纯合子强代谢组的治愈率显著低于弱代谢组(P＜0.05).弱代谢型组患者的Hpylori清除率显著高于纯合子强代谢型和杂合子强代谢型(P＜0.05).结论 CYP2C19基因多态性与奥美拉唑治疗十二指肠溃疡合并幽门螺旋菌感染的疗效密切相关.CYP2C19基因分型检测是临床治疗酸相关性疾病中的一个重要的工具. |
| 关 键 词： | CYP2C19 基因多态性 奥美拉唑 幽门螺旋菌 |
Effects of genotypic differences of CYP2C19 on duodenal ulcer therapy with omeprazole |
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| LI Hao , WU Jin-shu , ZHANG Wei , GONG Lian-sheng , LIU Gang , LIU Qin , TAN Liang , WANG Rong-bing. Effects of genotypic differences of CYP2C19 on duodenal ulcer therapy with omeprazole[J]. China Journal of Endoscopy, 2011, 17(8) | |
| Authors: | LI Hao WU Jin-shu ZHANG Wei GONG Lian-sheng LIU Gang LIU Qin TAN Liang WANG Rong-bing |
| Affiliation: | LI Hao1,WU Jin-shu1,ZHANG Wei2,GONG Lian-sheng3,LIU Gang3,LIU Qin3,TAN Liang3,WANG Rong-bing3(1.Department of Hepatobiliary Surgery,Hunan Provincial People's Hospital,Changsha,Hunan 410002,P.R.China,2.Institute of Clinical Pharmacology,Central South University,Hunan 410078,3.National Hepatobiliary and Enteric Surgery Research Center,Ministry of Public Health,Xiangya Hospital,Hunan 410008,P.R.China) |
| Abstract: | [Objective] We intended to evaluate endoscopically a cure rate for Helicobacter pylori infection by dual rabeprazole/amoxicillin therapy in relation to CYP2C19 genotype status prospectively.[Methods] Sixty-five patients with gastritis and H.pylori infection completed the dual therapy with 20 mg of omeprazole bid,1000 mg of amoxicillin bid and clarithromycin 500 mg bid for 1 week.Then omeprazole was medicated at the dose of 20 mg bid to inhibit gastric acid secretion.CYP2C19 genotype status was determined by... |
| Keywords: | CYP2C19 genetic polymorphis omeprazole Hpylori |
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