Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers |
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| Authors: | Ordookhani Arash Mirmiran Parvin Walfish Paul G Azizi Fereidoun |
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| Affiliation: | a Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
b Endocrine Division, Department of Medicine, Mount Sinai Hospital, University of Toronto Medical School, Toronto, Ontario, Canada. |
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| Abstract: | Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with "transient hyperthyrotropinemia and normal" diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397). |
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| Keywords: | CH, Congenital hypothyroidism T4, Total thyroxine TCH, Transient congenital hypothyroidism TgAb, Antithyroglobulin antibodies THAb, Thyroid hormone autoantibodies THT, Transient hyperthyrotropinemia TPOAb, Thyroid peroxidase antibodies TRAb, Thyrotropin receptor autoantibodies TSH, Thyrotropin UIC, Urinary iodine concentration US, Ultrasonography |
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