| 菝葜皂苷元对胃癌BGC-823细胞增殖、凋亡影响的实验研究 |
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| 引用本文： | 廖子君,张晓明,郭亚焕,孙海凤. 菝葜皂苷元对胃癌BGC-823细胞增殖、凋亡影响的实验研究[J]. 陕西肿瘤医学, 2010, 18(6): 1085-1087 |
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| 作者姓名： | 廖子君 张晓明 郭亚焕 孙海凤 |
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| 作者单位： | [1]陕西省肿瘤医院,陕西西安710061 [2]成阳市第一人民医院,陕西咸阳712000 |
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| 基金项目： | 陕西省卫生厅科学研究基金项目（编号：06D09） |
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| 摘 要： | 目的：观察不同浓度菝葜皂苷元对体外培养胃癌BGC-823细胞增殖、凋亡的影响.方法：BGC-823细胞经不同浓度菝葜皂苷元处理后,采用MTT法检测细胞的生长活性,流式细胞仪检测细胞凋亡.结果：随菝葜皂苷元浓度的增加,胃癌BGC-823细胞增殖抑制率、凋亡率亦升高.结论：菝葜皂苷元对胃癌BGC-823细胞的增殖有抑制作用,并可诱导细胞凋亡.
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| 关 键 词： | 菝葜皂苷元 胃癌BGC-823细胞株 凋亡 |
Study on the effect of proliferation and apoptosis of sarsasapogenin to human gastric cancer line B6C-823 |
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| LIAO Zi-jun,ZHANG Xiao-ming,GU Ya-huan,SUN Hai-feng. Study on the effect of proliferation and apoptosis of sarsasapogenin to human gastric cancer line B6C-823[J]. Shaanxi Oncology Medicine, 2010, 18(6): 1085-1087 |
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| Authors: | LIAO Zi-jun ZHANG Xiao-ming GU Ya-huan SUN Hai-feng |
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| Affiliation: | 1 Tumor Hospital of Shaanxi Province,Xi＇an 710061, China ; 2 The First People＇s Hospital of Xianyang City,Xianyang 712000, China.) |
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| Abstract: | Objective ：To investigate the effec of proliferation and apoptosis of human gastric cancer cell line BGC -823 cultured in vitro under different concentration. Methods ：The BGC -823 cells were treated by sarsasapogenin in different concentration and variable durations cell growth activity were observed using MTr assay;Flow eytometry was used to assay the effec of sarsasapogenin on apoptosis. Results： The rate of proliferation restrain and apoptosis of BGC -823 cell were significantly augment. Condusion：Sarsasapogenin can efficiently inhibit the proliferation and induce apoptosis of BGC - 823 cell. |
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| Keywords: | sarsasapogenin cell line BGC - 823 apoptosis |
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