| 醋炔诺酮肟的抗着床作用及其毒性研究 |
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| 引用本文： | 张寅恭,卢凤英,沈康元,桑国卫,石其贤,赵秀菊,刘放.醋炔诺酮肟的抗着床作用及其毒性研究[J].生殖与避孕,1981(4). |
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| 作者姓名： | 张寅恭 卢凤英 沈康元 桑国卫 石其贤 赵秀菊 刘放 |
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| 作者单位： | 浙江人民卫生实验院计划生育研究所
(张寅恭，卢凤英，沈康元，桑国卫，石其贤，赵秀菊)，浙江人民卫生实验院计划生育研究所(刘放) |
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| 摘 要： | 醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1～2毫克/公斤(约为临床剂量50～100倍),连服14个月,无明显毒性。
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STUDIES ON THE ANTI-IMPLANTATION EFFECT OF NORETHI-STERONE-OXIME-ACETATE AND ITS TOXICITY |
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| Abstract: | A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about 500 times as much as the clinical dose)for 3 weeks,and all were nor-mal in blood routine and renal function tests but a raised change was shown in their liverfunction(completely restored 2 weeks after cessation of the drug).3 dogs were given the drug at the dose of 1-2 mg/kg/day(about 50-100 times as muchas the clinical dose )for 14 months,no obvious toxic effect being observed. |
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