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| 心脑肾康对自由基清除作用的实验研究 | |
| 引用本文： | 简洁,李春凤,梁钢,徐庆.心脑肾康对自由基清除作用的实验研究[J].中国老年学杂志,2006,26(9):1237-1238. |
| 作者姓名： | 简洁 李春凤 梁钢 徐庆 |
| 作者单位： | 1. 桂林医学院药理教研室,广西,桂林,541004 2. 桂林医学院附属医院医务部 3. 广西医科大学药理教研室 |
| 摘 要： | 目的研究心脑肾康对自由基的清除作用。方法连续给大鼠灌胃心脑肾康7d后，以线栓法建立大脑中动脉梗死（MCAO）缺血再灌注模型，缺血1．5h再灌注24h后断头取脑，检测大脑皮层丙二醛（MDA）、超氧化物歧化酶（SOD）、一氧化氮（NO）、活性氧（ROS）、谷胱甘肽（GSH）含量。结果与模型组相比，商、中、低3个剂量心脑肾康用药后均能显著降低缺血后脑组织匀浆中MDA、NO、ROS含量，增加SOD、GSH活性（P〈0．05）并呈剂量依赖性。其中，高剂量效果最好，优于阳性对照药（P〈0．05）。结论心脑肾康具有良好的自由基清除作用。 |
| 关 键 词： | 心脑肾康 自由基 清除作用 |
| 文章编号： | 1005-9202（2006）09-1237-02 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2006-07-20 |
Experimental study the effects of XNSK on scavenging free radical |
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| JIAN Jie,LI Chun-Feng,LIANG Gang,et al..Experimental study the effects of XNSK on scavenging free radical[J].Chinese Journal of Gerontology,2006,26(9):1237-1238. | |
| Authors: | JIAN Jie LI Chun-Feng LIANG Gang |
| Institution: | Department of Pharmacology, Guilin Medical College, Guilin 541004, Guangxi, China |
| Abstract: | Objective To study the effects of Xinnaoshenkang(XNSK) on scavenging free radical.Methods The focal brain ischemia-reperfusion(middle cerebral artery occlusion,MCAO) model of rats given XNSK by intragastrical injection(i.g.) for 7 days were made by intraluminal monofilament method for 1.5 h and then reperfused for 24 h to detect the contents of MDA,NO,ROS,GSH and SOD in cerebral cortex homogenates from rats.Results XNSK at high,middle and low dosage decreased contents of MDA,NO,ROS and increased activity of SOD,GSH significantly(P<0.05) comparing model group,having dosage dependency.The high dosage had the best effect than positive control group(P<0.05).Conclusions XNSK has good effects on scavenging free radical. |
| Keywords: | XNSK Free radical Scavenging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |