高渗盐液灌流对烧伤大鼠离体心脏的作用

目的　观察高渗盐液对烧伤后大鼠心脏功能的影响。　方法　采用大鼠离体心脏灌流模型 ,用等渗和含 2 15mmol/LNa 的改良Krebs-Henseleit液灌流正常及烧伤后大鼠心脏 ,观察灌流过程中心脏功能的变化。　结果　无论正常还是烧伤动物心脏高渗盐溶液灌流最初均有短暂的心肌收缩、舒张功能抑制 ,但是能很快恢复 ;在从高渗换为等渗溶液时有一个心脏收缩、舒张功能显著增强的过程。高渗溶液对烧伤后大鼠心脏的收缩和舒张功能变化的影响更为显著。　结论　高渗盐液灌流能明显影响心脏收缩、舒张功能 ,此作用的强弱与心脏的基础状态有关

The effects of hypertonic saline solution perfusion on the isolated hearts of burned rats

Objective To observe the effect of hypertonic saline solution perfusion on the function of isolated hearts of burned rats. Methods The isolated rat heart was taken as the model. The hearts from normal control and burned rats were perfused by improved isotonic (Na 118 mmol/L) and hypertonic Krebs-Henseleit (Na 215 mmol/L) solutions, respectively. The dynamic changes of the cardiac function were monitored during heart perfusion. Results The cardiac contractive and diastolic function were transiently inhibited and followed by quick recovery during the perfusion with hypertonic solution in both control and burned rat hearts. But when the hypertonic solution was replaced by isotonic, there appeared significant enhancement of the cardiac contractive and diastolic function. These findings indicated that hypertonic solution exerted more powerful influence on the contractive and diastolic function of burned rat heart. Conclusion Hypertonic saline solution could influence the cardiac contractile and diastolic function significantly. And the magnitude of the effects was correlated with the basic cardiac condition.