| 腹部肠管火器伤后肝组织COX-2的表达与内毒素血症的关系 |
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| 引用本文： | 刘江伟,吕月涛,薛会朝,张永久,冯德元,许永华,李建英. 腹部肠管火器伤后肝组织COX-2的表达与内毒素血症的关系[J]. 创伤外科杂志, 2008, 10(4): 304-307 |
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| 作者姓名： | 刘江伟 吕月涛 薛会朝 张永久 冯德元 许永华 李建英 |
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| 作者单位： | 兰州军区乌鲁木齐总医院肝胆外科,新疆,乌鲁木齐,830000;兰州军区鸟鲁木齐总医院,动物实验中心,新疆,乌鲁木齐,830000 |
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| 摘 要： | 目的 探讨环氧化酶-2(COX-2)在腹部肠管火器伤后肝组织中表达的变化及其与肠源性内毒素血症的关系.方法 健康长白仔猪42头随机等分为对照组和伤后1、2、4、8、12、24小时组,实验组建立腹部火器伤肠管穿透模型后,用显色基质鲎试剂法检测各组血浆内毒素水平;免疫组化图像分析法测定各组肝组织COX-2的表达,同时测定血清中谷丙转氨酶(ALT)水平.结果 伤后各组血浆内毒素水平、肝组织COX-2的表达及血清ALT水平均明显高于对照组(P＜0.05).血浆内毒素水平于伤后8小时出现高峰,伤后12小时仍维持在高峰值水平;肝组织COX-2的表达及血清ALT水平均于伤后2小时和12小时出现2个高峰.相关分析表明,伤后肝组织COX-2与血浆内毒素及血清ALT水平均呈正相关(r值分别为0.718、0.850,P＜0.05).结论 腹部肠管火器伤后COX-2的表达与内毒素血症密切相关,COX-2在腹部肠管火器伤继发性肝损伤中可能起重要作用.
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| 关 键 词： | 环氧化酶-2 内毒素 腹部损伤 火器伤 肝损伤 |
Relationship between expressions of hepatic COX-2 and intestinal endotoxemia after intestinal firearm wound |
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| LIU Jiang-wei,LU Yue-tao,XUE Hui-chao,et al.. Relationship between expressions of hepatic COX-2 and intestinal endotoxemia after intestinal firearm wound[J]. Journal of Traumatic Surgery, 2008, 10(4): 304-307 |
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| Authors: | LIU Jiang-wei LU Yue-tao XUE Hui-chao et al. |
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| Affiliation: | LIU Jiang-wei,LU Yue-tao,XUE Hui-chao,et al.(Department of Hepatobiliary Surgery,Urumuqi General Hospital of Lanzhou Military Comm,,PLA,Urumuqi 830000,China) |
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| Abstract: | Objective To investigate the changes of expressions of hepatic COX-2 and the relationship between hepatic COX-2 and intestinal endotoxemia after intestinal firearm wound.Methods A total of 42 Chang-Bai piglets were randomized into 7 groups: control group and wounded 1,2,4,8,12,24 hour groups.The models of intestinal firearm wound were established in wounded groups.Levels of plasma endotoxin was measured by using chromogenic limulus amebocyte lysate test;Hepatic COX-2 expression were measured with immunohist... |
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| Keywords: | cycloxygenase-2 endotoxin abdominal injuries firearm wound liver injury |
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