| 43例皮肌炎患者皮损及肌肉直接免疫荧光检查分析 |
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| 引用本文： | 李维云,肖尹,纪华安,薛丑文,王萍,丁素先. 43例皮肌炎患者皮损及肌肉直接免疫荧光检查分析[J]. 中国中西医结合皮肤性病学杂志, 2004, 3(2): 86-88 |
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| 作者姓名： | 李维云 肖尹 纪华安 薛丑文 王萍 丁素先 |
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| 作者单位： | 1. 天津市长征医院皮肤科,天津,300021
2. 天津武警总队机关医院,天津,300042 |
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| 摘 要： | 目的探讨皮肌炎的发病机理.方法采用抗人Ig(IgG、IgM、IgA和补体C3)DIF技术,检查了43例皮肌炎患者肌肉组织和其中21例皮肌炎患者皮肤损害的荧光分布.结果皮肌炎患者肌肉组织IgG、IgM、IgA和补体C3的阳性率分别为72.09%、23.26%、11.63%和51.16%,分布于肌膜;皮损区IgG、IgM、IgA和补体C3的阳性率分别为66.67%、19.05%、4.76%和61.90%,分布于基底膜.患者外周血IgG水平明显升高(70.83%).结论体液免疫亢进在皮肌炎的发病机理中起重要作用.
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| 关 键 词： | 皮肌炎 皮损 肌肉 直接免疫荧光 |
| 文章编号： | 1672-0709(2004)02-0086-03 |
| 修稿时间： | 2004-05-08 |
Analysis on Skin Lesions and Muscles of 43 Cases of Dermatomyositis by Direct Immunofluorescence Method |
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| LI Wei-yun,XIAO Yin,JI Hua-an,XUE Chou-wen,WANG Ping,DING Su-xian. Analysis on Skin Lesions and Muscles of 43 Cases of Dermatomyositis by Direct Immunofluorescence Method[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2004, 3(2): 86-88 |
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| Authors: | LI Wei-yun XIAO Yin JI Hua-an XUE Chou-wen WANG Ping DING Su-xian |
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| Affiliation: | LI Wei-yun,XIAO Yin,JI Hua-an,XUE Chou-wen,WANG Ping,DING Su-xian1.Department of Dermatology,Tianjin Changzheng Hospital,Tianjin 300021,China,2.Tianjin Armed Police Headquarters Organ Hospital,Tianjin 300042,China |
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| Abstract: | Objective To investigate the pathogenesis of dermatomyositis. Methods Expression and distribution of immunoglobulin (IgG, IgM, IgA ) and C3 by direct immunofluorescence method in 43 patients. Results Positive rates of IgG, IgM, IgA and C3 were 72.09%, 23.26%, 11.63% and 51.16% respectively on musclar membran, and 66.67%,19.05%,4.76% and 61.90% respectively in epithelial basic membran in skin lesions. Levels of serum IgG also increased remarkably. Conclusion The body fluid hyper-immunofunction may play an important role in pathogenesis of dermatomyositis. |
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| Keywords: | dermatomyositis skin lesion muscle direct immunity fluorescence |
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