Disseminated CD8‐positive,CD30‐positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation |
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Authors: | Jonathan J. Davick Krishna A. J. Mutgi Karolyn A. Wanat Brian K. Link Vincent Liu |
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Affiliation: | 1. Department of Pathology, University of Virginia, Charlottesville, Virginia;2. Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa;3. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa;4. Department of Medicine, Division of Hematology‐Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa |
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Abstract: | CD8‐positive, CD30‐positive cutaneous lymphoproliferative disorders constitute a rare subset of T‐cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma‐delta T‐cell lymphoma and cutaneous peripheral T‐cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73‐year‐old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. To our knowledge, this is the first case of a generalized CD8+, CD30+ eruption with features of both mycosis fungoides and primary cutaneous ALCL arising following an episode of solitary primary cutaneous CD8‐positive ALCL. |
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Keywords: | anaplastic large cell
CD30
CD8
cutaneous T‐cell lymphoma lymphoma mycosis fungoides |
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