Congenital neurocristic cutaneous hamartoma with poliosis: A case report |
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| Authors: | Lauren M. Wilson Knox J. Beasley Timothy C. Sorrells Viviana V. Johnson |
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| Affiliation: | 1. Eastern Virginia Medical School, Norfolk, Virginia;2. Department of Dermatology, McDonald Army Health Center, Ft. Eustis, Virginia;3. Departments of Dermatology and Pathology, Naval Medical Center Portsmouth, Portsmouth, Virginia |
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| Abstract: | Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57‐year‐old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian‐differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S‐100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain (HMB‐45, Melan A, Tyrosinase) and S‐100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis. |
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| Keywords: | congenital cutaneous hamartoma neurocristic poliosis |
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