糖尿病大鼠血栓调节蛋白与颈动脉病变的关系

目的:探讨血栓调节蛋白在糖尿病大鼠颈动脉病变中的作用。方法:Wistar大鼠48只随机分为A组24只和B组24只,B组注射链脲佐菌素制造糖尿病模型。成模后6、10和14周每组处死8只,测定颈动脉内中膜厚度、血糖、体重、血栓调节蛋白、空腹胰岛素、C肽及血脂水平。结果:随病程延长,B组空腹血糖、血栓调节蛋白、总胆固醇、甘油三酯及低密度脂蛋白显著高于A组,胰岛素、C肽及高密度脂蛋白显著低于A组;B组右颈动脉内中膜厚度在10,14周时较A组厚度明显增加;B组颈动脉内中膜厚度与血栓调节蛋白呈显著正相关。结论:糖尿病大鼠血栓调节蛋白升高与颈动脉病变显著相关,血栓调节蛋白升高先于颈动脉病理改变的发生,可能成为糖尿病颈动脉病变发生的重要早期预测指标。

Study on the relationship between TM and carotid artery lesion in diabetic rats

Objective: To explore the role and relationship of thrombomodulin (TM) in the development of carotid artery le- sion in DM and provide the foundation in early stage of carotid artery lesion occurred in DM. Methods: 48 Wistar rats were randomly divided into two groups. There were 24 in both groups respectively. The subjects in group B were injected with streptozotocin (50 mg/kg). After six, ten and fourteen weeks, their blood samples were obtained to measure the levels of TM, FINS,C-peptide,TG, TC, HDL and L...