首页 | 本学科首页   官方微博 | 高级检索  
     


Amphetamine and tranylcypromine in an animal model of depression: Pharmacological specificity of the reversal effect
Authors:R.J. Katz  K.A. Roth  K. Schmaltz
Affiliation:Mental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109 USA
Abstract:Amphetamine and tranylcypromine are structurally related chemical isomers with pharmacologically distinctive activity profiles. Since they are equimolar and structurally similar they may be used to assess the pharmacological specificity of a proposed animal model of depression. Adult male Sprague-Dawley rats were exposed to a chronic stress regimen or remained undisturbed. They were then acutely stressed with white noise. The monoamine oxidase inhibitor tranylcypromine was effective in restoring otherwise reduced stress elicited open field activity in chronically stressed rats. Amphetamine did not resemble tranylcypromine or other antidepressants, and produced a variety of effects at least some of which indicated a potential increase rather than reduction in depression consequent to chronic administration.
Keywords:Activity  Ambulation  Amphetamine  Animal model of depression  Antidepressant  Defecation  Monoamine oxidase inhibitor  Open field  Stress  Tranylcypromine
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号