| 活血化瘀方对大鼠急性胃粘膜损伤的保护作用及机理研究 |
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| 引用本文： | 张正 王汝俊 等. 活血化瘀方对大鼠急性胃粘膜损伤的保护作用及机理研究[J]. 中药药理与临床, 1997, 13(1): 24-26 |
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| 作者姓名： | 张正 王汝俊 等 |
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| 作者单位： | 广州中医药大学脾胃研究所 |
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| 摘 要： | 本实验观察了活血化瘀药物（丹参、赤芍、川芎、莪术组成）水提液对盐酸乙醇致急性胃粘膜损伤的保护作用，结果显示活血化瘀方5．4g/kg、10．8g/kg、21．6g/kg对损伤模型具有很好的保护作用，并呈明显的量效关系；预先灌胃10．8g/kg能显著抑制盐酸乙醇引起的大鼠血浆过氧化脂质含量升高，对红细胞超氧化物歧化酶活性降低有抑制趋势。
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| 关 键 词： | 胃粘膜损伤 活血化瘀药物 过氧化脂质 超氧化物歧化酶 保护作用 药理学 |
Protective effect of blood-activating drugs on acute gastric mucosal injury |
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| Zhang Zheng. Protective effect of blood-activating drugs on acute gastric mucosal injury[J]. Pharmacology and Clinics of Chinese Materia Medica, 1997, 13(1): 24-26 |
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| Authors: | Zhang Zheng |
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| Abstract: | Rat animal model of acute gastric mucosal injury was induced by enthanol-HCl to study the protective effect of blood-activating drugs (BAD) on acute gastric mucosal injury.Blood- activating decoction was given prior to enthanol-HCl. The results indicate that pretreatment with BAD can significantly atlenuate the gastric mucosal injury and the protective effect has relation with dose, it also can reduce LPO content and increase SOD activity. It is suggested that the BAD has protective effect on gastric mucosal injury,it might be due to improvment of gastric mucosal defence mechanism and scavenging function of oxygen free radicals. |
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| Keywords: | gastric mucosal injury superoxide blood-activating drugs (BAD) |
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