Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor. |
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Authors: | R G Wiley T N Oeltmann D A Lappi |
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Affiliation: | Neurology Service, DVAMC, Nashville, TN 37212-2637. |
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Abstract: | 192 IgG, a monoclonal antibody to the rat nerve growth factor (NGF) receptor, was disulfide-coupled to saporin, a ribosome-inactivating protein. Systemic injection of 192 IgG-saporin destroyed sympathetic postganglionic neurons and some sensory neurons. Injection of 192 IgG-saporin into the lateral ventricle destroyed cholinergic neurons of the basal forebrain. These results show that antineuronal immunotoxins are a powerful approach that may prove useful in a variety of neurobiological applications. |
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