| 甲基毒死蜱毒理学研究 |
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| 引用本文： | 宋瑞琨,李龙,赖志伟,邬惠琼,马谭庚,孙黎,刘毓谷.甲基毒死蜱毒理学研究[J].华中科技大学学报(医学版),1992(Z1). |
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| 作者姓名： | 宋瑞琨 李龙 赖志伟 邬惠琼 马谭庚 孙黎 刘毓谷 |
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| 作者单位： | 同济医科大学公共卫生学院环境毒理学教研室
(宋瑞琨，李龙，赖志伟，邬惠琼，马谭庚，孙黎)，同济医科大学公共卫生学院环境毒理学教研室(刘毓谷) |
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| 摘 要： | 甲基毒死蜱是一种高效广谱的有机磷农药,用作储粮保护剂,其杀虫效果优于沿用已久的马拉硫磷。作者通过一系列毒性试验,对其毒性作用进行了研究,并从亚细胞水平对其代谢机理进行了初步探讨。结果表明,甲基毒死蜱属低毒性农药,蓄积性小,未发现致突变性、致畸性、生殖毒性和迟发性神经毒性。在体内代谢迅速,消除快,残留小,主要代谢场所为肝细胞微粒体和可溶性胞浆。是一种较为安全的粮食储藏保护剂。
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| 关 键 词： | 甲基毒死蜱 毒物代谢动力学 免疫毒性 微粒体 |
Toxicologkal Studies on Chlorpyrifos-methyl |
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| Song Ruikun,Li Long,Lai Zhiwei,Wu HuiqiongMa Tangen,Sun Li,Liu Yugu.Toxicologkal Studies on Chlorpyrifos-methyl[J].Journal of Huazhong University of Science and Technology(Health Sciences),1992(Z1). |
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| Authors: | Song Ruikun Li Long Lai Zhiwei Wu HuiqiongMa Tangen Sun Li Liu Yugu |
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| Institution: | Song Ruikun,Li Long,Lai Zhiwei,Wu HuiqiongMa Tangen,Sun Li,Liu Yugu Department of Environmental Toxicology,School of Public Health,Tongji Medical University,Wuhan |
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| Abstract: | A series of toxicological tests of chlorpyrifos-methyl were performed. The results showed that chlorpyrifos-methyl is metabolized quickly in the body and has only a very low toxicity and cumulative toxicity. No mutagenicity, teratogtenicity, reproductive toxicity and delayed neurotoxicity were observed. The liver is a main site of metabolism of chlorpyrifos-methyl. In liver cells ,the main sites of metabolism are cytoplasm and microsomes. |
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| Keywords: | chlorpyrifos-methyl toxicokinetics immunotoxlcity microsome |
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