大动脉炎易感性与HLA-DRB基因相关性研究

目的 探讨大动脉炎易感性与ＨＬＡ－ＤＲＢ等位基因频率的相关性。方法 以８４例汉族大动脉炎患和１０２例健康汉族人（对照组）为研究对象，采用ＰＣＲ－ＳＳＰ及ＰＣＲ－ＲＦＬＰ方法进行ＨＬＡ－ＤＲＢ等位基因分型，比较其等位基因频率在大动脉炎患与对照组之间的差异。结果 ＨＬＡ－ＤＲ４、ＤＲ７等位基因频率在大动脉炎组显高于对照组（３８．１％比１５．７％，Ｐ〈０．０１，ＲＲ＝２．４３；４７．６％比１０．８

Relationship between the susceptibility to aortoarteritis and HLA-DRB gene

Objective To investigate the relationship between aortoarteritis and HLA DRB alleles gene in Chinese Han. Methods HLA DRB genotype was identified by PCR SSP and PCR RFLP in 84 aortoarteritis patients and 102 healthy controls. Results Compared with controls, the frequencies of HLA DR4 and DR7 in the aortoarteritis group increased significantly (38 10% vs 15 7%, P<0 001, RR= 2 43; 47 6% vs 10 8%, P< 0 001, RR= 4 42, respectively), DRB4 was also higher than that in the control group (85 7% vs 42 2%. P< 0 001, RR= 2 03). But HLA DR512 and DRB3 decreased remarkably (21 4% vs 33 3%, P= 0 05, RR= 0 62; 50 0% vs 70 6%, P=0 004, RR= 0 71, respectively). Further more, there was no significant difference in the frequency of DRB1*0405 subtypes between the patients and control group. Conclusions The susceptibility to aortoarteritis in Chinese Han is closely related to gene DR4 and DR7. HLA DR4 and DR7 are susceptible genes of aortoarteritis. People with HLA DR4 and DR7 have a higher risk of suffering from aortoarteritis.