| 中国北方汉族寻常型天疱疮与HLA-Ⅱ类基因单倍型的相关性研究 |
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| 引用本文： | 耿龙,翟宁,韩秀萍,牛红喜,宋芳吉.中国北方汉族寻常型天疱疮与HLA-Ⅱ类基因单倍型的相关性研究[J].中国免疫学杂志,2006,22(5):453-455. |
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| 作者姓名： | 耿龙 翟宁 韩秀萍 牛红喜 宋芳吉 |
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| 作者单位： | 1. 中国医科大学附属第一医院皮肤科,沈阳,110001
2. 中国医科大学附属第二医院皮肤科,沈阳,110003 |
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| 摘 要： | 目的：探讨HLA—DR、DQ基因单倍型与中国东北地区汉族人寻常型天疱疮的相关性。方法：应用序列特异性引物-聚合酶链反应（PCR—SSP）技术对27例中国东北汉族PV患者的HLA—DRB1、DQB1等位基因测定，进行单倍型分析，并与99例健康对照者进行比较。结果：与对照组比较，寻常型天疱疮患者组中单倍型DRB1＊140x-DQB1＊0503、DRB1＊140x-DQB1＊0201、DRB1＊120x-DQB1＊0503和DRB1＊140x—DQB1＊0302的频率明显增高，经统计学检验差异有显著意义（P〈0．05）。结论：特异单倍型可能是决定寻常型天疱疮发生的重要因素。
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| 关 键 词： | 寻常型天疱疮 HLA-DR、DQ 单倍型 中国人 |
| 文章编号： | 1000-484X（2006）05-0453-03 |
| 收稿时间： | 2005-11-28 |
| 修稿时间： | 2005-11-282006-01-25 |
Study of association between HLA class Ⅱ haplotypes and pemphigus vulgaris in Han nation of northeast China |
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| GENG Long,ZHAI Ning,HAN Xiu-Ping,NIU Hong-Xi,SONG Fang-Ji.Study of association between HLA class Ⅱ haplotypes and pemphigus vulgaris in Han nation of northeast China[J].Chinese Journal of Immunology,2006,22(5):453-455. |
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| Authors: | GENG Long ZHAI Ning HAN Xiu-Ping NIU Hong-Xi SONG Fang-Ji |
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| Institution: | Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, China |
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| Abstract: | Objective:To investigate the relationship between pemphigus vulgaris(PV) and HLA-DR,DQ haplotypes in Han nations of northeast China.Methods:Polymerase chain reaction-sequence specific primers(PCR-SSP) method was used to detect the HLA-DRB1 and DQB1 alleles of 27 PV patients of Han nation of northeast China, analysed haplotyes and compared with 99 healthy controls.Results:Compared with control group, the frequencies of the haplotypes of HLA-DRB1*140x-DQB1*0503,DRB1*140x-DQB1*0201,DRB1*120x-DQB1*0503 and DRB1*140x-DQB1*0302 increased significantly in PV group. After statistical test, the difference between the two groups was significant.Conclusion:The special haplotypes may contribute to genetic susceptibility to PV in northeast Chinese. |
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| Keywords: | Pemphigus vulgaris HLA-DR DQ Haplotype Chinese |
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